Phylogenetic analysis and prevalence of Delta hepatitis among HBsAg carriers in Afghanistan

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dc.authorscopusid56194505100
dc.authorscopusid57790739300
dc.contributor.authorHusseini, Abbas Ali
dc.contributor.authorRostamzadeh, Mehran
dc.date.accessioned2024-09-11T19:58:27Z
dc.date.available2024-09-11T19:58:27Z
dc.date.issued2022
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractThe molecular profile of hepatitis Delta in Afghanistan remains unclear yet, therefore this study addresses the genotype of HDV among HBsAg carriers in Afghanistan. In total 234 HBsAg-positive sera were examined by chemiluminescent micro-particle immunoassay to detect Anti-HDV antibodies. Serologically positive samples were later approved via real-time PCR test and subsequently, a 731 bp segment of the HDV Delta antigen RNA region was sequenced in the Illumina platform. The isolates were genotyped via distance matrix/UPGMA analysis using Kimura 2-parameter by MEGA7 software package program. The HBV/HDV coinfection rate among HBsAg carriers in Afghanistan was 2.1%. Finally, 4 samples successfully amplified Hepatitis delta antigen (HDAg) which Later in phylogenetic analysis, all resided in branch genotype I and were stored at GenBank with accession numbers MK799645, MK799646, MK799647, MK799648. The HDV genotypic variations in the Afghan HBsAg carriers may be homogenous and HDV-1 may be the predominant genotype in Afghanistan © 2022, Molecular Biology Research Communications.All Rights Reserved.en_US
dc.identifier.doi10.22099/mbrc.2022.44692.1780
dc.identifier.endpage186en_US
dc.identifier.issn2322-181Xen_US
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85146671460en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage183en_US
dc.identifier.urihttps://doi.org/10.22099/mbrc.2022.44692.1780
dc.identifier.urihttps://hdl.handle.net/11363/8488
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherShiraz Universityen_US
dc.relation.ispartofMolecular Biology Research Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectAfghanistan; Genotype; Hepatitis delta; Phylogenetic analysisen_US
dc.titlePhylogenetic analysis and prevalence of Delta hepatitis among HBsAg carriers in Afghanistanen_US
dc.typeArticleen_US

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