EFFECT OF TWEEN 80 ON THE STABILITY AND CONFORMATION OF TELOMERIC G-QUADRUPLEX DNA

Elhaty, Ismail A.2024-09-112024-09-1120231996-4196https://doi.org/10.23939/chcht17.03.567https://hdl.handle.net/11363/8041G-quadruplex DNA is formed in telomer. It inhibits telomerase enzyme which is found active in more than 85 % of cancer cells. In this work, the effect of Tween 80 on telomeric G-quadruplex DNA, AGGG(TTAGGG)3 was studied using circular dichroism spectroscopic technique. The obtained results showed that using Tween 80 with telomeric quadruplex is safe up to less than 1.0 %.eninfo:eu-repo/semantics/openAccesstelomerequadruplexTween 80circular dichroismconformationEFFECT OF TWEEN 80 ON THE STABILITY AND CONFORMATION OF TELOMERIC G-QUADRUPLEX DNAArticle17356757310.23939/chcht17.03.5672-s2.0-85178349199WOS:001127616800026Q4