Shirzad, Mohammad MusaOzadali-Sari, KerimanUnsal-Tan, OyaHusseini, Abbas AliPalaska, Erhan2024-09-112024-09-1120240091-150X1573-9031https://doi.org/10.1007/s11094-024-03136-8https://hdl.handle.net/11363/7624Thiadiazole and triazole-5-thione derivatives are five membered heterocyclic compounds showing cyclooxygenase inhibition activities. Based on this observation a series of novel aryloxymethyl 1,3,4-thiadiazole and 1,2,4-triazole-5-thione derivatives were synthesized and their biological activities evaluated. The suggested chemical structure of synthesized compounds was confirmed using FT-IR, Mass, 1H-NMR, and 13C-NMR spectrometric methods and elemental analysis. The biological activity or potency of synthesized compounds was evaluated using a COX inhibitor screening assay kit (Cayman Chemical Company), and indomethacin and NS398 as standard compounds. Compounds 2b and 3b showed good inhibitory activity against COX-2 and COX-1 enzymes respectively. The obtained data indicate that compound 2b is more selective to COX-2 and compound 3b is more selective to COX-1 compared with other synthesized compounds. These two compounds show promising selectivity and could be a starting point for future research in this area.eninfo:eu-repo/semantics/closedAccessthiadiazoletriazolecyclooxygenaseinflammationdockingArticle58220921510.1007/s11094-024-03136-82-s2.0-85197641439WOS:001252346500009N/A