Minor hemoglobins HbA2 and HbF associate with disease severity in bipolar disorder with a likely protective role of HbA2 against post-partum episodes

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dc.authorscopusid36165113000
dc.authorscopusid57215571180
dc.authorscopusid13003955900
dc.authorscopusid55247771000
dc.authorscopusid57213083022
dc.authorscopusid6602275861
dc.contributor.authorInce, Bahri
dc.contributor.authorGuloksuz, Sinan
dc.contributor.authorAltinbaş, Kürat
dc.contributor.authorOral, Esat Timuçin
dc.contributor.authorAlpkan, Latif Ruhat
dc.contributor.authorAltinoz, Meric A.
dc.date.accessioned2024-09-11T19:57:28Z
dc.date.available2024-09-11T19:57:28Z
dc.date.issued2013
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractBackground: There exist studies indicating that bipolar disorder (BD) associates with changes in brain blood flow. Human brain with its high demand to oxygen constitutes 2% of the total body weight, while it receives 20% of cardiac output. and 3 globin chains of hemoglobin were recently found in neural tissues, yet no study has questioned blood hemoglobins in BR Methods: A total of 120 euthymic BD patients (40 males and 80 females) were analyzed via high performance liquid chromatography (HPLC) to measure minor hemoglobin levels, which were statistically compared with disease characteristics. Results: Minor hemoglobins HbA2 and HbF associated positively with episode density as a measure of disease severity in BR An increased level of HbA2 meant significantly less postpartum episodes in child bearing women. HbF levels were higher in patients with a positive family history of any psychotic disorder. Sum of HbA2 and HbF correlated with episode density with a stronger significance (p <0001) supporting intermittent hypoxia hypothesis in BR Limitations: The study was conducted only on euthymic patients to avoid likely bigger exogenous effects such as electro-convulsive therapy and diverse drug regimes, yet larger comparative studies are needed to support our current findings. Conclusions: Higher HbA2 and HbF in more severe bipolar disorder may be compensations against intermittent hypoxias in BR HbA2 increases following myocardial angina and in mountain dwellers, which may indicate protective roles in extreme conditions. HbF increase may act more as a maladaptation or emerge via haplotypal associations of BD genes and gamma-globin locus at II p155. © 2013 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.jad.2013.06.042
dc.identifier.endpage408en_US
dc.identifier.issn0165-0327en_US
dc.identifier.issue1en_US
dc.identifier.pmid23856286en_US
dc.identifier.scopus2-s2.0-84888639256en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage405en_US
dc.identifier.urihttps://doi.org/10.1016/j.jad.2013.06.042
dc.identifier.urihttps://hdl.handle.net/11363/8279
dc.identifier.volume151en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofJournal of Affective Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectBipolar disorder; Episode density; Fetal hemoglobin; Hemoglobin A2; Intermittent hypoxia; Postpartum episodeen_US
dc.titleMinor hemoglobins HbA2 and HbF associate with disease severity in bipolar disorder with a likely protective role of HbA2 against post-partum episodesen_US
dc.typeArticleen_US

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