Synthesis and Antibacterial Activity of Rhodanine-Based Azo Dyes and Their Use as Spectrophotometric Chemosensor for Fe3+ Ions

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dc.authoridhttps://orcid.org/0000-0003-4492-2181en_US
dc.contributor.authorAkram, Dana
dc.contributor.authorElhaty, Ismail A. M.
dc.contributor.authorAlNeyadi, Shaikha S.
dc.date.accessioned2023-08-20T09:00:46Z
dc.date.available2023-08-20T09:00:46Z
dc.date.issued2020en_US
dc.departmentSağlık Bilimleri Fakültesien_US
dc.description.abstractThis research includes the design and synthesis of new derivatives for rhodanine azo compounds (4a–c) containing a naphthalene ring. Physiochemical properties of the synthesized compounds were determined by their melting points, FTIR, 1H-NMR, 13C-NMR, and elemental analysis spectroscopic techniques. The biological activities of the newly prepared azo rhodanine compounds were evaluated against some pathogenic bacteria using three different bacterial species including (Escherichia coli., Pseudomonas aeruginosa, Staphylococcus aureus) and compared with amoxicillin as a reference drug. The results showed that our compounds have moderate-to-good vital activity against the mentioned pathogenic bacteria. The selectivity and sensitivity of the newly prepared rhodanine azo compounds with transition metals Co2+, Cu2+, Zn2+, Ni2+, and Fe3+ were studied using UV–vis and fluorescence spectroscopy techniques. Among the synthesized azos, azo 4c showed affinity toward Fe3+ ions with an association constant of 4.63 × 108 M?1 . Furthermore, this azo showed high sensitivity toward Fe3+ ions with detection limits of 5.14 µM. The molar ratio and Benesi–Hildebrand methods confirmed the formation of complexes between azo 4c and Fe3+ with 1:2 binding stoichiometry. Therefore, azo 4c showed excellent potential for developing efficient Fe3+ chemosensors.en_US
dc.identifier.doi10.3390/chemosensors8010016en_US
dc.identifier.endpage13en_US
dc.identifier.issn2227-9040
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85082177311en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/11363/5390
dc.identifier.urihttps://doi.org/
dc.identifier.volume8en_US
dc.identifier.wosWOS:000525031100008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorElhaty, Ismail A. M.
dc.language.isoenen_US
dc.publisherMDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLANDen_US
dc.relation.ispartofChemosensorsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectfluorescenceen_US
dc.subjectsynthesisen_US
dc.subjectrhodanineen_US
dc.subjectFe3+ sensingen_US
dc.subjectUV/vis spectrometryen_US
dc.titleSynthesis and Antibacterial Activity of Rhodanine-Based Azo Dyes and Their Use as Spectrophotometric Chemosensor for Fe3+ Ionsen_US
dc.typeArticleen_US

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