Relationship between abnormalities on high-resolution computerized tomography, pulmonary function, and bronchoalveolar lavage in progressive systemic sclerosis

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dc.authorscopusid21742147900
dc.authorscopusid57193844929
dc.authorscopusid57195968845
dc.authorscopusid7004338095
dc.authorscopusid8357943700
dc.authorscopusid6507190513
dc.authorscopusid9735975200
dc.contributor.authorCakmak, Gulfidan
dc.contributor.authorCan, Tuba Selcuk
dc.contributor.authorGungogdu, Sule
dc.contributor.authorAkman, Canan
dc.contributor.authorIkitimur, Hande
dc.contributor.authorMusellim, Benan
dc.contributor.authorOngen, Gul
dc.date.accessioned2024-09-11T19:57:37Z
dc.date.available2024-09-11T19:57:37Z
dc.date.issued2016
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractIntroduction and aim: Progressive systemic sclerosis (pSS) is a multisystemic connective tissue disease characterized by fibrosis of the skin and internal organs including lung. The mechanisms that leads to progressive lung fibrosis in scleroderma remain obscure. In this study, we aimed to investigate the correlation between HRCT findings and patients' clinical and functional status and the degree of alveolitis based on the BAL results. Materials and methods: 65 patients with pSS were evaluated. Thoracic HRCT, pulmonary function tests, and dyspnea measurements were applied, and BAL was performed. The parenchymal abnormalities identified on HRCT were coded, and scored according to Warrick et al. Results: Among parameters investigated, a correlation was found between the number of segments with subpleural cysts and the duration of disease. Also there was a correlation between the HRCT score and patient age whereas no correlation was detected between the duration of the disease, manifestation of the symptoms, and the x-ray findings. A correlation was found between the percentage of neutrophils detected in BAL and the extent of the honeycombing on HRCT. Conclusion: This study showed a strong correlation between the extent of x-ray abnormalities and FVC, RV, and DLCO, as well as an increase in the percentage of BAL fluid neutrophils in patients with SSc-PI. © Mattioli 1885.en_US
dc.identifier.endpage354en_US
dc.identifier.issn1124-0490en_US
dc.identifier.issue4en_US
dc.identifier.pmid28079847en_US
dc.identifier.scopus2-s2.0-85028500724en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage349en_US
dc.identifier.urihttps://hdl.handle.net/11363/8319
dc.identifier.volume33en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMattioli 1885en_US
dc.relation.ispartofSarcoidosis Vasculitis and Diffuse Lung Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectHigh Resolution Computed Tomography; Pulmonary Function Test; Sclerodermaen_US
dc.titleRelationship between abnormalities on high-resolution computerized tomography, pulmonary function, and bronchoalveolar lavage in progressive systemic sclerosisen_US
dc.typeArticleen_US

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