The ameliorative effects of Nigella sativa, thymoquinone, and bentonite against aflatoxicosis in broilers via AFAR and Nrf2 signalling pathways, and down-regulation of caspase-3

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dc.authorscopusid57210434352
dc.authorscopusid6602352947
dc.authorscopusid7006798955
dc.authorscopusid57196709151
dc.authorscopusid57196002965
dc.authorscopusid7003969030
dc.authorscopusid6602521213
dc.contributor.authorAtes, M.B.
dc.contributor.authorOrtatatli, M.
dc.contributor.authorOguz, H.
dc.contributor.authorOzdemir, O.
dc.contributor.authorTerzi, F.
dc.contributor.authorCiftci, M.K.
dc.contributor.authorHatipoglu, F.
dc.date.accessioned2024-09-11T19:57:25Z
dc.date.available2024-09-11T19:57:25Z
dc.date.issued2022
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstract1. Aflatoxins (AFs) are metabolites which especially have toxic effects on proteins, and are detoxified by the aflatoxin-B1 aldehyde reductase (AFAR) pathway. In this pathway, the aldo-keto reductase family 7, member A2 (AKR7A2) enzyme, which is controlled by nucleic-related erythroid factor 2 (Nrf2), plays an active role. However, data on the efficacy of this critical pathway in broilers is limited. 2. The aim of the following study was to investigate the changes in the expression levels of AKR7A2, Nrf2, and caspase-3, and the effects of Nigella sativa seeds (NS), thymoquinone (TMQ), and bentonite (BNT) in broilers exposed to AFs. 3. One-hundred broilers were divided into ten groups (control (CNT); AF; NS; TMQ; BNT; AF+TMQ; AF+NS; AF+BNT; AF+BNT+NS; AF+BNT+TMQ) and fed for 28 d. AF, TMQ, NS and BNT were added to diets at levels of 2 mg/kg, 300 mg/kg, 50 g/kg and 10 g/kg respectively. 4. The addition of AF to the diet decreased AKR7A2 and Nrf2 levels dramatically, but increased caspase-3 (P < 0.01). TMQ, NS and BNT additions to the diet eliminated all negative effects caused by AF (P < 0.01); and AKR7A2 and Nrf2 were further raised in TMQ and NS groups when compared to the control group. TMQ and NS showed a positive effect on detoxification parameters when given together with BNT. 5. Supplementation with NS and TMQ enhanced AF detoxification via the AFAR pathway, by increasing AKR7A2 and Nrf2 levels, in addition to reducing hepatocyte apoptosis. © 2021 British Poultry Science Ltd.en_US
dc.description.sponsorshipSelcuk University Scientific Research Projects Coordination Office, (18401102); Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAK, (117O872)en_US
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) under Grant number [117O872]; and Selcuk University Scientific Research Projects Coordination Office under Grant number [18401102].en_US
dc.identifier.doi10.1080/00071668.2021.1998366
dc.identifier.endpage339en_US
dc.identifier.issn0007-1668en_US
dc.identifier.issue3en_US
dc.identifier.pmid34738498en_US
dc.identifier.scopus2-s2.0-85121124245en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage332en_US
dc.identifier.urihttps://doi.org/10.1080/00071668.2021.1998366
dc.identifier.urihttps://hdl.handle.net/11363/8253
dc.identifier.volume63en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofBritish Poultry Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectAKR7A2; apoptosis; black cumin; liver; Mycotoxin; Nrf2en_US
dc.titleThe ameliorative effects of Nigella sativa, thymoquinone, and bentonite against aflatoxicosis in broilers via AFAR and Nrf2 signalling pathways, and down-regulation of caspase-3en_US
dc.typeArticleen_US

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