Is there a relationship between infertility and fertilin ? protein distribution?
dc.authorscopusid | 57193081360 | |
dc.authorscopusid | 6602494132 | |
dc.authorscopusid | 57198053953 | |
dc.contributor.author | Gundogan, Gul Ipek | |
dc.contributor.author | Irez, Tulay | |
dc.contributor.author | Bozkurt, Hasan Hakan | |
dc.date.accessioned | 2024-09-11T19:57:58Z | |
dc.date.available | 2024-09-11T19:57:58Z | |
dc.date.issued | 2022 | |
dc.department | İstanbul Gelişim Üniversitesi | en_US |
dc.description.abstract | Introduction: Fertilin ? is a sperm surface protein that can mediate sperm-egg membrane interaction. This study was conducted to determine whether the expression of fertilin ? after intrauterine insemination (IUI) in donors with normal parameters after standard semen analysis is related to low success rate or failure of fertilization. Methods: We examined the sperm of 30 male donors who have normal as controls, oligozoospermia, and unexplained infertility as the clinically indication for IUI. Fertilin ? has been labeled with the ADAM2 antibody by indirect immunofluorescence (IF) assay. To evaluate the reproducibility of the test, we selected four sperm samples scale of 0 to +++ according to the distribution of fluorescence label. Results: The results were highly correlated with the corrected total cell fluorescence (CTCF) (Rp = 0.9972, P < 0.05). We suggest that the relationship between infertility and fertilin ? may be due to the distribution of this protein on the sperm surface. Male partners of couples with unexplained infertility showed a low distribution of fertilin ? by a decrease of the fluorescence signal in the IF labeling (scale of +++ by 7.4 ± 10.32%, P < 0.0001, ±SD). Discussion: Abnormal fertilin ? function may be a potential mechanism that could lead to fertilization failure. © 2022 Asociación Española de Andrología, Medicina Sexual y Reproductiva | en_US |
dc.description.sponsorship | Istanbul Üniversitesi, (21093) | en_US |
dc.description.sponsorship | This work was supported by the Scientific Research Projects Coordination Unit of Istanbul University . Project number: 21093 | en_US |
dc.identifier.doi | 10.1016/j.androl.2021.04.003 | |
dc.identifier.endpage | 248 | en_US |
dc.identifier.issn | 1698-031X | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.pmid | 35933293 | en_US |
dc.identifier.scopus | 2-s2.0-85135388951 | en_US |
dc.identifier.scopusquality | Q3 | en_US |
dc.identifier.startpage | 240 | en_US |
dc.identifier.uri | https://doi.org/10.1016/j.androl.2021.04.003 | |
dc.identifier.uri | https://hdl.handle.net/11363/8381 | |
dc.identifier.volume | 20 | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Ediciones Doyma, S.L. | en_US |
dc.relation.ispartof | Revista Internacional de Andrologia | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.snmz | 20240903_G | en_US |
dc.subject | Andrology; Fertility; Oligozoospermia; Sperm; Surface proteins; Unexplained infertility | en_US |
dc.title | Is there a relationship between infertility and fertilin ? protein distribution? | en_US |
dc.title.alternative | ¿Existe relación entre la infertilidad y la distribución de la proteína fertilin ??] | en_US |
dc.type | Article | en_US |